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KMID : 0363320180390061150
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Journal of Korean Oriental Internal Medicine
2018 Volume.39 No. 6 p.1150 ~ p.1167
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Xuefuzhuyu Decoction for Essential Hypertension: Meta-Analysis and Systemic Review
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Han In-Sik
Jang In-Soo
Sun Seung-Ho
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Abstract
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Objective: The purpose of this study was to investigate the effect reducing blood pressure (BP) using Xuefuzhuyu Decoction (XFZYD) in adults with essential hypertension (EH).
Method: Search engine, such as PubMed, EMBASE, Cochrane library, Web of Science, J-STAGE, CiNii, CNKI, OASIS, NDSL, KISS, RISS, and DBpia, were used. The search period was from the beginning of the search engine to June 30, 2018 and there were no limits regarding languages. The selection and extraction of literatures were performed independently by two authors. Meta-analysis was done on the total effective rate (TER), Systolic BP (SBP) and Diastolic BP (DBP). Cochrane’s risk of bias (ROB) was used as the methodological quality assessment scale.
Results: Twenty studies were finally selected. We observed that a combination treatment using XFZYD and an antihypertensive drug (AHD) was 5.1 times more effective in lowering BP than using AHD alone on TER. The mean differences in SBP and DBP were -10.65 mmHg (95% Confidential Interval (CI) -13.55 mmHg, -7.74 mmHg, P<0.00001), -5.92 mmHg (95% CI -7.14, -4.38, P<0.00001), respectively.
Conclusion: A combination treatment using XFZYD and AHD may be more effective in reducing BP than using AHD alone. Because of the poor methodological quality of the studies conducted thus far, high-quality clinical trials will be required in the future.
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KEYWORD
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herbal medicine, hypertension, systemic review, meta-analysis, Xuefuzhuyu decoction
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